Play Mario Run and Gun unblocked- help the popular character Mario run and jump his way through levels while blasting bad guys with fireballs in the great platform game. Mario Run and Gun is a tricky arcade game where you must safely guide the running Mario through many challenging levels filled with spikes, obstacles, enemies, and other dangerous elements! How to play: Control Mario using the Arrow Up, Down, Left, and Right Keys on your computer keyboard. Press the Spacebar to fire a special water ball (The water ball eliminates some enemies and certain obstacles such as rolling barrels). Mario Run and Gun unblocked is rated E for everyone.